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New England, San Diego and Indianapolis where known as the preseason ''Big Three.'' A name earned as owners of enormous favoritism to win their respective divisions, AFC and Super Bowl. For those who invested in the Big Three, now's the time to look away, as we glance back at the colossal respect given to the trio by those in charge of NFL odds prior to regular-season kickoff.

The Patriots were heavy lumber across the BetUS NFL odds board to win everything, at -1000 AFC East chalk, +175 to win conference and Super Bowl faves at +350. The Chargers were -400 to win its division, +450 to win conference and +750 to take the Super Bowl. The Colts were -175 to earn division title, +500 to claim AFC and +750 to win the NFL championship.

With Tom Brady out, bolts turned sparks and Colts two amazing come from behind victories away from being 0-4, which of the Big Three has best chances of reaching postseason? Answer: Patriots and Chargers, who will treat the NFL wagering fans to a Sunday evening (8:15pm EST) showdown at Qualcomm Stadium in a huge game for both. The Patriots are 2-8 ATS in their last ten overall, meanwhile, the Chargers are a sharp 8-1 ATS in their last 9 homies.

Matt Cassell is doing a good job replacing Brady and San Diego is much better than their record indicates, these two of the Big Three are in control of their own destination. However, Indianapolis needs a complete Tennessee meltdown, which is unlikely from the best team in football.